Framework

When designing a drug, we…

1. Decide our goal.  Is it to --
1. Temporarily repair the issue? (i.e., monoclonal antibodies for chronically secreted oncoproteins / attack the symptoms)
2. Completely repair / fix the issue / attack the cause? (i.e., change the DNA to fix the core cause of the clinical symptoms)
3. Remove and replace the issue? (i.e., remove the bad cell/organ and replace it with a healthy organ.  This differs from complete repair when the removal/replacement is removing some good as well as bad)
4. Remove and/or kill the issue? (i.e., cause cell-death and/or remove the harmful component)
2. Look at Our Four Guiding Principles of Design
1. Regional Localization
2. Specificity towards target
3. Potency / magnitude (dosage + combinatory effect), with our goal ("1") in mind.
4. ADME personalizations

                                                              i.      Any ensuing potential side effects